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An Enantio‐ and Diastereoselective Chemoenzymatic Synthesis of α‐Fluoro β‐Hydroxy Carboxylic Esters

The trans‐o‐hydroxybenzylidene pyruvate aldolase‐catalysed reactions between fluoropyruvate and many (hetero)aromatic aldehydes yield aldol adducts without subsequent dehydration. Treatment of the reaction products with hydrogen peroxide yields the corresponding syn‐configured α‐fluoro β‐hydroxy car...

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Bibliografski detalji
Izdano u:Angew Chem Int Ed Engl
Glavni autori: Howard, James K., Müller, Marion, Berry, Alan, Nelson, Adam
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074308/
https://ncbi.nlm.nih.gov/pubmed/27090612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201602852
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