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An Enantio‐ and Diastereoselective Chemoenzymatic Synthesis of α‐Fluoro β‐Hydroxy Carboxylic Esters

The trans‐o‐hydroxybenzylidene pyruvate aldolase‐catalysed reactions between fluoropyruvate and many (hetero)aromatic aldehydes yield aldol adducts without subsequent dehydration. Treatment of the reaction products with hydrogen peroxide yields the corresponding syn‐configured α‐fluoro β‐hydroxy car...

詳細記述

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書誌詳細
出版年:Angew Chem Int Ed Engl
主要な著者: Howard, James K., Müller, Marion, Berry, Alan, Nelson, Adam
フォーマット: Artigo
言語:Inglês
出版事項: John Wiley and Sons Inc. 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074308/
https://ncbi.nlm.nih.gov/pubmed/27090612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201602852
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