Tributyrin Inhibits Ethanol-Induced Epigenetic Repression of CPT-1A and Attenuates Hepatic Steatosis and Injury

Ethanol-mediated down-regulation of carnitine palmitoyltransferase-1 (CPT-1A) gene expression plays a major role in the development of hepatic steatosis; however, the underlying mechanisms are not completely elucidated. Tributyrin, a butyrate prodrug that can inhibit histone deacetylase (HDAC) activ...

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Udgivet i:Cell Mol Gastroenterol Hepatol
Main Authors: Donde, Hridgandh, Ghare, Smita, Joshi-Barve, Swati, Zhang, JingWen, Vadhanam, Manicka V., Gobejishvili, Leila, Lorkiewicz, Pawel, Srivastava, Sanjay, McClain, Craig J., Barve, Shirish
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2019
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7078548/
https://ncbi.nlm.nih.gov/pubmed/31654770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2019.10.005
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