Binge Alcohol-Induced Microvesicular Liver Steatosis and Injury are Associated with Down-Regulation of Hepatic Hdac 1, 7, 9, 10, 11 and Up-Regulation of Hdac 3

BACKGROUND: Binge, as well as chronic, alcohol consumption affects global histone acetylation leading to changes in gene expression. It is becoming increasingly evident that these histone associated epigenetic modifications play an important role in the development of alcohol-mediated hepatic injury...

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Published in:Alcohol Clin Exp Res
Main Authors: Kirpich, Irina, Ghare, Smita, Zhang, Jingwen, Gobejishvili, Leila, Kharebava, Giorgi, Barve, Swati Joshi, Barker, David, Moghe, Akshata, McClain, Craig, Barve, Shirish
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867116/
https://ncbi.nlm.nih.gov/pubmed/22375794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1530-0277.2012.01751.x
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