Binge Ethanol-Induced HDAC3 Down-Regulates Cpt1α Expression Leading to Hepatic Steatosis and Injury

BACKGROUND: Recently, we have demonstrated that acute alcohol exposure due to binge drinking leads to hepatic steatosis with the deregulation of hepatic histone deacetylase (HDAC) expression. Various class I, II, and IV HDACs were down-regulated, whereas expression of HDAC3 was solely up-regulated....

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Hlavní autoři: Kirpich, Irina, Zhang, Jingwen, Gobejishvili, Leila, Kharebava, Giorgi, Barker, David, Ghare, Smita, Joshi-Barve, Swati, McClain, Craig J., Barve, Shirish
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3975907/
https://ncbi.nlm.nih.gov/pubmed/23905631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acer.12172
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