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Mitochondrial ClpX activates an essential biosynthetic enzyme through partial unfolding

Mitochondria control the activity, quality, and lifetime of their proteins with an autonomous system of chaperones, but the signals that direct substrate-chaperone interactions and outcomes are poorly understood. We previously discovered that the mitochondrial AAA+ protein unfoldase ClpX (mtClpX) ac...

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Pubblicato in:eLife
Autori principali: Kardon, Julia R, Moroco, Jamie A, Engen, John R, Baker, Tania A
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7077987/
https://ncbi.nlm.nih.gov/pubmed/32091391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.54387
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