Mitochondrial ClpX activates a key enzyme for heme biosynthesis and erythropoiesis

The mitochondrion maintains and regulates its proteome with chaperones primarily inherited from its bacterial endosymbiont ancestor. Among these chaperones is the AAA+ unfoldase ClpX, an important regulator of prokaryotic physiology with poorly defined function in the eukaryotic mitochondrion. We ob...

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Publicado en:Cell
Autores principales: Kardon, Julia R., Yien, Yvette Y., Huston, Nicholas C., Branco, Diana S., Hildick-Smith, Gordon J., Rhee, Kyu Y., Paw, Barry H., Baker, Tania A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467794/
https://ncbi.nlm.nih.gov/pubmed/25957689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.04.017
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