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Structure of the Mitochondrial Aminolevulinic Acid Synthase, a Key Heme Biosynthetic Enzyme
5-aminolevulinic acid synthase (ALAS) catalyzes the first step in heme biosynthesis. We present the crystal structure of a eukaryotic ALAS from S. cereivisae. In this homodimeric structure, one ALAS subunit contains covalently bound cofactor, pyridoxal 5’-phosphate (PLP), whereas the second is PLP-f...
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| Publicado no: | Structure |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5894356/ https://ncbi.nlm.nih.gov/pubmed/29551290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2018.02.012 |
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