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Down-Regulation of Aminolevulinate Synthase, the Rate-Limiting Enzyme for Heme Biosynthesis in Alzheimer’s Disease
Heme is an essential cell metabolite, intracellular regulatory molecule, and protein prosthetic group. Given the known alterations in heme metabolism and redox metal distribution and the up regulation of heme oxygenase enzyme in Alzheimer’s disease (AD), we hypothesized that heme dyshomeostasis play...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2743886/ https://ncbi.nlm.nih.gov/pubmed/19477221 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2009.05.058 |
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