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Molecular enzymology of 5-Aminolevulinate synthase, the gatekeeper of heme biosynthesis

Pyridoxal-5'-phosphate (PLP) is an obligatory cofactor for the homodimeric mitochondrial enzyme 5-aminolevulinate synthase (ALAS), which controls metabolic flux into the porphyrin biosynthetic pathway in animals, fungi, and the α-subclass of proteobacteria. Recent work has provided an explanati...

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Detalhes bibliográficos
Main Authors: Hunter, Gregory A., Ferreira, Gloria C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3090494/
https://ncbi.nlm.nih.gov/pubmed/21215825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2010.12.015
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