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Molecular enzymology of 5-Aminolevulinate synthase, the gatekeeper of heme biosynthesis
Pyridoxal-5'-phosphate (PLP) is an obligatory cofactor for the homodimeric mitochondrial enzyme 5-aminolevulinate synthase (ALAS), which controls metabolic flux into the porphyrin biosynthetic pathway in animals, fungi, and the α-subclass of proteobacteria. Recent work has provided an explanati...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3090494/ https://ncbi.nlm.nih.gov/pubmed/21215825 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2010.12.015 |
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