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Targeting the Active Site Gate to Yield Hyperactive Variants of 5-Aminolevulinate Synthase
The rate of porphyrin biosynthesis in mammals is controlled by the activity of the pyridoxal 5′-phosphate-dependent enzyme 5-aminolevulinate synthase (EC 2.3.1.37). Based on the postulate that turnover in this enzyme is controlled by conformational dynamics associated with a highly conserved active...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2859533/ https://ncbi.nlm.nih.gov/pubmed/20194506 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.074237 |
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