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Serine 254 Enhances an Induced Fit Mechanism in Murine 5-Aminolevulinate Synthase
5-Aminolevulinate synthase (EC 2.3.1.37) (ALAS), a pyridoxal 5′-phosphate (PLP)-dependent enzyme, catalyzes the initial step of heme biosynthesis in animals, fungi, and some bacteria. Condensation of glycine and succinyl coenzyme A produces 5-aminolevulinate, coenzyme A, and carbon dioxide. X-ray cr...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2823457/ https://ncbi.nlm.nih.gov/pubmed/19917609 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.066548 |
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