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Targeting the Active Site Gate to Yield Hyperactive Variants of 5-Aminolevulinate Synthase

The rate of porphyrin biosynthesis in mammals is controlled by the activity of the pyridoxal 5′-phosphate-dependent enzyme 5-aminolevulinate synthase (EC 2.3.1.37). Based on the postulate that turnover in this enzyme is controlled by conformational dynamics associated with a highly conserved active...

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Autors principals: Lendrihas, Thomas, Hunter, Gregory A., Ferreira, Gloria C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859533/
https://ncbi.nlm.nih.gov/pubmed/20194506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.074237
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