Unstable Reaction Intermediates and Hysteresis during the Catalytic Cycle of 5-Aminolevulinate Synthase: IMPLICATIONS FROM USING PSEUDO AND ALTERNATE SUBSTRATES AND A PROMISCUOUS ENZYME VARIANT

5-Aminolevulinate (ALA), an essential metabolite in all heme-synthesizing organisms, results from the pyridoxal 5′-phosphate (PLP)-dependent enzymatic condensation of glycine with succinyl-CoA in non-plant eukaryotes and α-proteobacteria. The predicted chemical mechanism of this ALA synthase (ALAS)-...

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Detalhes bibliográficos
Main Authors: Stojanovski, Bosko M., Hunter, Gregory A., Jahn, Martina, Jahn, Dieter, Ferreira, Gloria C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132793/
https://ncbi.nlm.nih.gov/pubmed/24920668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.574731
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