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Asn-150 of Murine Erythroid 5-Aminolevulinate Synthase Modulates the Catalytic Balance between the Rates of the Reversible Reaction
5-Aminolevulinate synthase (ALAS) catalyzes the first step in mammalian heme biosynthesis, the pyridoxal 5′-phosphate (PLP)-dependent and reversible reaction between glycine and succinyl-CoA to generate CoA, CO(2), and 5-aminolevulinate (ALA). Apart from coordinating the positioning of succinyl-CoA,...
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| Publicado no: | J Biol Chem |
|---|---|
| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4692205/ https://ncbi.nlm.nih.gov/pubmed/26511319 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.655399 |
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