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Histidine-282 in 5-Aminolevulinate Synthase Affects Substrate Binding and Catalysis
5-Aminolevulinate synthase (ALAS), the first enzyme of the heme biosynthetic pathway in mammalian cells, is member of the α-oxoamine synthase family of pyridoxal 5′-phosphate (PLP)-dependent enzymes. In all structures of the enzymes of the α-oxoamine synthase family, a conserved histidine hydrogen b...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2566939/ https://ncbi.nlm.nih.gov/pubmed/17469798 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi062053k |
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