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Histidine-282 in 5-Aminolevulinate Synthase Affects Substrate Binding and Catalysis

5-Aminolevulinate synthase (ALAS), the first enzyme of the heme biosynthetic pathway in mammalian cells, is member of the α-oxoamine synthase family of pyridoxal 5′-phosphate (PLP)-dependent enzymes. In all structures of the enzymes of the α-oxoamine synthase family, a conserved histidine hydrogen b...

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Autori principali: Turbeville, Tracy D., Zhang, Junshun, Hunter, Gregory A., Ferreira, Gloria C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2566939/
https://ncbi.nlm.nih.gov/pubmed/17469798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi062053k
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