Novel mitochondrion‐targeting copper(II) complex induces HK2 malfunction and inhibits glycolysis via Drp1‐mediating mitophagy in HCC

[Cu(ttpy‐tpp)Br(2)]Br (abbreviated as CTB) is a novel mitochondrion‐targeting copper(II) complex synthesized by our research group, which contains tri‐phenyl‐phosphonium (TPP) groups as its lipophilic property. In this study, we explored how CTB affects mitochondrial functions and exerts its anti‐tu...

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Veröffentlicht in:J Cell Mol Med
Hauptverfasser: Li, Mengmeng, Shao, Jiangjuan, Guo, Zijian, Jin, Chun, Wang, Ling, Wang, Feixia, Jia, Yan, Zhu, Zhenzhu, Zhang, Ziji, Zhang, Feng, Zheng, Shizhong, Wang, Xiaoyong
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7077532/
https://ncbi.nlm.nih.gov/pubmed/31994339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14971
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