Blockade of glycolysis-dependent contraction by oroxylin a via inhibition of lactate dehydrogenase-a in hepatic stellate cells

BACKGROUND: Contraction of hepatic stellate cells (HSCs) plays an important role in the pathogenesis of liver fibrosis by regulating sinusoidal blood flow and extracellular matrix remodeling. Here, we investigated how HSC contraction was affected by the natural compound oroxylin A, and elucidated th...

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Publicado en:Cell Commun Signal
Main Authors: Wang, Feixia, Jia, Yan, Li, Mengmeng, Wang, Ling, Shao, Jiangjuan, Guo, Qinglong, Tan, Shanzhong, Ding, Hai, Chen, Anping, Zhang, Feng, Zheng, Shizhong
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2019
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6371416/
https://ncbi.nlm.nih.gov/pubmed/30744642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-019-0324-8
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