Ligand Activation of PPARγ by Ligustrazine Suppresses Pericyte Functions of Hepatic Stellate Cells via SMRT-Mediated Transrepression of HIF-1α

Rationale: Hepatic stellate cells (HSCs) are liver-specific pericytes regulating vascular remodeling during hepatic fibrosis. Here, we investigated how ligustrazine affects HSC pericyte functions. Methods: Rat HSC-T6 and human HSC-LX2 cells were cultured, and multiple molecular experiments including...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Zhang, Feng, Lu, Shuai, He, Jianlin, Jin, Huanhuan, Wang, Feixia, Wu, Li, Shao, Jiangjuan, Chen, Anping, Zheng, Shizhong
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5771080/
https://ncbi.nlm.nih.gov/pubmed/29344293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.22237
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