TPP-related mitochondrial targeting copper (II) complex induces p53-dependent apoptosis in hepatoma cells through ROS-mediated activation of Drp1

BACKGROUND: In recent years, copper complexes have gradually become the focus of potential anticancer drugs due to their available redox properties and low toxicity. In this study, a novel mitochondrion-targeting copper (II) complex, [Cu (ttpy-tpp)Br(2)] Br (simplified as CTB), is first synthesized...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Commun Signal
Main Authors: Shao, Jiangjuan, Li, Mengmeng, Guo, Zijian, Jin, Chun, Zhang, Feng, Ou, Chunyan, Xie, Yaochen, Tan, Shanzhong, Wang, Zhenyi, Zheng, Shizhong, Wang, Xiaoyong
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6862763/
https://ncbi.nlm.nih.gov/pubmed/31744518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-019-0468-6
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados