Engineered immunogen binding to alum adjuvant enhances humoral immunity

Adjuvants are central to the efficacy of subunit vaccines. Aluminum hydroxide (alum) is the most commonly used vaccine adjuvant, yet its adjuvanticity is often weak and mechanisms of triggering antibody responses remain poorly understood. We demonstrate that site-specific modification of immunogens...

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Vydáno v:Nat Med
Hlavní autoři: Moyer, Tyson J., Kato, Yu, Abraham, Wuhbet, Chang, Jason Y. H., Kulp, Daniel W., Watson, Nicki, Turner, Hannah L., Menis, Sergey, Abbott, Robert K., Bhiman, Jinal N., Melo, Mariane B., Simon, Hayley A., Herrera-De la Mata, Sara, Liang, Shu, Seumois, Gregory, Agarwal, Yash, Li, Na, Burton, Dennis R., Ward, Andrew B., Schief, William R., Crotty, Shane, Irvine, Darrell J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group US 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7069805/
https://ncbi.nlm.nih.gov/pubmed/32066977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-020-0753-3
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