Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo

How antigen valency affects B cells in vivo during immune responses is not well understood. Here, using HIV immunogens with defined valencies ranging from 1 to 60, we investigated the role of antigen valency during different phases of B cell responses in vivo. Highly multimerized immunogens preferen...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Kato, Yu, Abbott, Robert K., Freeman, Brian L., Haupt, Sonya, Groschel, Bettina, Silva, Murillo, Menis, Sergey, Irvine, Darrell J., Schief, William R., Crotty, Shane
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Inc. 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7451196/
https://ncbi.nlm.nih.gov/pubmed/32857950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2020.08.001
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