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In vivo RNAi screens: concepts and applications

Functional genomics approaches that leverage the RNA interference (RNAi) pathway have been applied in vivo to examine the roles of hundreds or thousands of genes, mainly in the context of cancer. Here we discuss principles guiding the design of RNAi screens, parameters that determine success and rec...

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Publicado en:Trends Immunol
Main Authors: Crotty, Shane, Pipkin, Matthew E.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810674/
https://ncbi.nlm.nih.gov/pubmed/25937561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.it.2015.03.007
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