Enhancing humoral immunity via sustained-release implantable microneedle patch vaccination

Sustained exposure of lymphoid tissues to vaccine antigens promotes humoral immunity, but traditional bolus immunizations lead to rapid antigen clearance. We describe a technology to tailor vaccine kinetics in a needle-free platform translatable to human immunization. Solid pyramidal microneedle (MN...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Boopathy, Archana V., Mandal, Anasuya, Kulp, Daniel W., Menis, Sergey, Bennett, Nitasha R., Watkins, Hannah C., Wang, Wade, Martin, Jacob T., Thai, Nikki T., He, Yanpu, Schief, William R., Hammond, Paula T., Irvine, Darrell J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2019
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6697788/
https://ncbi.nlm.nih.gov/pubmed/31358641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1902179116
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