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Lymphotoxin-β receptor-NIK signaling induces alternative RELB/NF-κB2 activation to promote metastatic gene expression and cell migration in head and neck cancer

Head and neck squamous cell carcinomas (HNSCC) preferentially spread to regional cervical tissues and lymph nodes. Here, we hypothesized that lymphotoxin-β (LTβ), receptor LTβR, and NF-κB-inducing kinase (NIK), promote the aberrant activation of alternative NF-κB2/RELB pathway and genes, that enhanc...

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Dades bibliogràfiques
Publicat a:Mol Carcinog
Autors principals: Das, Rita, Coupar, Jamie, Clavijo, Paul E., Saleh, Anthony, Cheng, Tsu-Fan, Yang, Xinping, Chen, Jianhong, VanWaes, Carter, Chen, Zhong
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7066987/
https://ncbi.nlm.nih.gov/pubmed/30488488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.22938
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