TGF-β and NF-κB signal pathway cross-talk is mediated through TAK1 and SMAD7 in a subset of head and neck cancers

TGF-β plays a dual role in epithelial malignancies, including head and neck squamous cell carcinoma (HNSCC). Attenuation of canonical TGF-β signaling enhances de novo tumor development, while TGF-β overexpression and signaling paradoxically promotes malignant progression. We recently observed that T...

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Autores principales: Freudlsperger, Christian, Bian, Yansong, Contag, Stephanie, Burnett, Jeffrey, Coupar, Jamie, Yang, Xinping, Chen, Zhong, Van Waes, Carter
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434281/
https://ncbi.nlm.nih.gov/pubmed/22641218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.171
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