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Lymphotoxin-β receptor-NIK signaling induces alternative RELB/NF-κB2 activation to promote metastatic gene expression and cell migration in head and neck cancer

Head and neck squamous cell carcinomas (HNSCC) preferentially spread to regional cervical tissues and lymph nodes. Here, we hypothesized that lymphotoxin-β (LTβ), receptor LTβR, and NF-κB-inducing kinase (NIK), promote the aberrant activation of alternative NF-κB2/RELB pathway and genes, that enhanc...

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Dettagli Bibliografici
Pubblicato in:Mol Carcinog
Autori principali: Das, Rita, Coupar, Jamie, Clavijo, Paul E., Saleh, Anthony, Cheng, Tsu-Fan, Yang, Xinping, Chen, Jianhong, VanWaes, Carter, Chen, Zhong
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7066987/
https://ncbi.nlm.nih.gov/pubmed/30488488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.22938
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