RelB is the NF-κB subunit downstream of NIK responsible for osteoclast differentiation

NF-κB inducing kinase (NIK) is required for osteoclastogenesis in response to pathologic stimuli, and its loss leads to functional blockade of both alternative and classical NF-κB caused by cytoplasmic retention by p100. We now show that deletion of p100 restores the capacity of NIK-deficient osteoc...

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Hauptverfasser: Vaira, Sergio, Johnson, Trevor, Hirbe, Angela C., Alhawagri, Muhammad, Anwisye, Imani, Sammut, Benedicte, O'Neal, Julie, Zou, Wei, Weilbaecher, Katherine N., Faccio, Roberta, Novack, Deborah Veis
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2008
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268780/
https://ncbi.nlm.nih.gov/pubmed/18322009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708576105
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