Aberrant IKKα and IKKβ cooperatively activate NF-κB and induce EGFR/AP1 signaling to promote survival and migration of head and neck cancer

The Inhibitor-κB Kinase-Nuclear Factor-κB (IKK-NF-κB) and Epidermal Growth Factor Receptor-Activator Protein-1 (EGFR-AP-1) pathways are often co-activated and promote malignant behavior, but the underlying basis for this relationship is unclear. Resistance to inhibitors of IKKβ or EGFR is observed i...

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Hlavní autoři: Nottingham, Liesl K., Yan, Carol H., Yang, Xinping, Si, Han, Coupar, Jamie, Bian, Yansong, Cheng, Tsu-Fan, Allen, Clint, Arun, Pattatheyil, Gius, David, Dang, Lenny, Van Waes, Carter, Chen, Zhong
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3926900/
https://ncbi.nlm.nih.gov/pubmed/23455325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.49
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