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Differential bortezomib sensitivity in head and neck cancer lines corresponds to proteasome, NF-κB and AP-1 related mechanisms
Head and neck squamous cell carcinomas (HNSCC) exhibit constitutive activation of transcription factors NF-κB and AP-1, which are modulated by the proteasome, and promote resistance to cell death. HNSCC show variable sensitivity to the proteasome inhibitor bortezomib in vitro, as well as in murine x...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2743084/ https://ncbi.nlm.nih.gov/pubmed/18645005 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-07-2046 |
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