Differential bortezomib sensitivity in head and neck cancer lines corresponds to proteasome, NF-κB and AP-1 related mechanisms

Head and neck squamous cell carcinomas (HNSCC) exhibit constitutive activation of transcription factors NF-κB and AP-1, which are modulated by the proteasome, and promote resistance to cell death. HNSCC show variable sensitivity to the proteasome inhibitor bortezomib in vitro, as well as in murine x...

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Main Authors: Chen, Zhong, Ricker, Justin L., Malhotra, Pramit S., Nottingham, Liesl, Bagain, Lorena, Lee, Tin Lap, Yeh, Ning T, Van Waes, Carter
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743084/
https://ncbi.nlm.nih.gov/pubmed/18645005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-07-2046
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