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TAK1 lysine 158 is required for TGF-β-induced TRAF6-mediated Smad-independent IKK/NF-κB and JNK/AP-1 activation

Lys63-linked TAK1 polyubiquitination plays an essential role in the regulation of TAK1 activation. TRAF6-mediated Lys63-linked polyubiquitilation of TAK1 has been shown to be required for TGF-β-induced TAK1 activation. However, it remains unclear which lysine residue on TAK1 is TRAF6-mediated TAK1 p...

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Bibliografiske detaljer
Main Authors: Mao, Renfang, Fan, Yihui, Mou, Yonggao, Zhang, Hong, Fu, Songbin, Yang, Jianhua
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2956842/
https://ncbi.nlm.nih.gov/pubmed/20837137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2010.09.006
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