Lysine 63-linked Polyubiquitination of TAK1 at Lysine 158 Is Required for Tumor Necrosis Factor α- and Interleukin-1β-induced IKK/NF-κB and JNK/AP-1 Activation

Transforming growth factor-β-activated kinase 1 (TAK1) plays an essential role in the tumor necrosis factor α (TNFα)- and interleukin-1β (IL-1β)-induced IκB kinase (IKK)/nuclear factor-κB (NF-κB) and c-Jun N-terminal kinase (JNK)/activator protein 1 (AP-1) activation. Here we report that TNFα and IL...

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Bibliografiske detaljer
Main Authors: Fan, Yihui, Yu, Yang, Shi, Yi, Sun, Wenjing, Xie, Min, Ge, Ningling, Mao, Renfang, Chang, Alex, Xu, Gufeng, Schneider, Michael D., Zhang, Hong, Fu, Songbin, Qin, Jun, Yang, Jianhua
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820763/
https://ncbi.nlm.nih.gov/pubmed/20038579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.076976
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