Lys63-linked polyubiquitination of BRAF at lysine 578 is required for BRAF-mediated signaling

The RAF kinase family is essential in mediating signal transduction from RAS to ERK. BRAF constitutively active mutations correlate with human cancer development. However, the precise molecular regulation of BRAF activation is not fully understood. Here we report that BRAF is modified by Lys63-linke...

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Main Authors: An, Lei, Jia, Wei, Yu, Yang, Zou, Ning, Liang, Li, Zhao, Yanling, Fan, Yihui, Cheng, Jin, Shi, Zhongcheng, Xu, Gufeng, Li, Grace, Yang, Jianhua, Zhang, Hong
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3731650/
https://ncbi.nlm.nih.gov/pubmed/23907581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02344
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