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Lysine 63-linked Polyubiquitination Is Dispensable for Parkin-mediated Mitophagy

PINK1/Parkin-mediated mitophagy is thought to ensure mitochondrial quality control in neurons as well as other cells. Upon the loss of mitochondrial membrane potential (ΔΨm), Lys-63-linked polyubiquitin chains accumulate on the mitochondrial outer membrane in a Parkin-dependent manner. However, the...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Shiba-Fukushima, Kahori, Inoshita, Tsuyoshi, Hattori, Nobutaka, Imai, Yuzuru
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2014
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246074/
https://ncbi.nlm.nih.gov/pubmed/25336644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C114.580944
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