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Lysine 63-linked Polyubiquitination Is Dispensable for Parkin-mediated Mitophagy
PINK1/Parkin-mediated mitophagy is thought to ensure mitochondrial quality control in neurons as well as other cells. Upon the loss of mitochondrial membrane potential (ΔΨm), Lys-63-linked polyubiquitin chains accumulate on the mitochondrial outer membrane in a Parkin-dependent manner. However, the...
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| Publié dans: | J Biol Chem |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4246074/ https://ncbi.nlm.nih.gov/pubmed/25336644 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C114.580944 |
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