Reduced TDP-43 Expression Improves Neuronal Activities in a Drosophila Model of Perry Syndrome

Parkinsonian Perry syndrome, involving mutations in the dynein motor component dynactin or p150(Glued), is characterized by TDP-43 pathology in affected brain regions, including the substantia nigra. However, the molecular relationship between p150(Glued) and TDP-43 is largely unknown. Here, we repo...

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Bibliografiske detaljer
Udgivet i:	EBioMedicine
Main Authors:	Hosaka, Yuka, Inoshita, Tsuyoshi, Shiba-Fukushima, Kahori, Cui, Changxu, Arano, Taku, Imai, Yuzuru, Hattori, Nobutaka
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2017
Fag:	Research Paper
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5514405/ https://ncbi.nlm.nih.gov/pubmed/28625517 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.06.002
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Reduced TDP-43 Expression Improves Neuronal Activities in a Drosophila Model of Perry Syndrome

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