A Cell-Based High-Throughput Screening Identified Two Compounds that Enhance PINK1-Parkin Signaling

Early-onset Parkinson's disease-associated PINK1-Parkin signaling maintains mitochondrial health. Therapeutic approaches for enhancing PINK1-Parkin signaling present a potential strategy for treating various diseases caused by mitochondrial dysfunction. We report two chemical enhancers of PINK1...

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Bibliographic Details
Published in:iScience
Main Authors: Shiba-Fukushima, Kahori, Inoshita, Tsuyoshi, Sano, Osamu, Iwata, Hidehisa, Ishikawa, Kei-ichi, Okano, Hideyuki, Akamatsu, Wado, Imai, Yuzuru, Hattori, Nobutaka
Format: Artigo
Language:Inglês
Published: Elsevier 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7183160/
https://ncbi.nlm.nih.gov/pubmed/32335362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101048
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