Tubulin is a molecular target of the Wnt-activating chemical probe

Por Fukuda, Yasunori, Sano, Osamu, Kazetani, Kenichi, Yamamoto, Koji, Iwata, Hidehisa, Matsui, Junji
Publicado no BMC Biochem (2016)

Using a biologically annotated library to analyze the anticancer mechanism of serine palmitoyl transferase (SPT) inhibitors

Por Sano, Osamu, Kazetani, Ken‐ichi, Adachi, Ryutaro, Kurasawa, Osamu, Kawamoto, Tomohiro, Iwata, Hidehisa
Publicado no FEBS Open Bio (2017)

Quantitative comparison of the mRNA content of human iPSC‐derived motor neurons and their extracellular vesicles

Por Otake, Kentaro, Adachi‐Tominari, Keiko, Nagai, Hiroaki, Saito, Masayo, Sano, Osamu, Hirozane, Yoshihiko, Iwata, Hidehisa
Publicado no FEBS Open Bio (2021)

A novel pyrrolo[3, 2‐d]pyrimidine derivative, as a vascular endothelial growth factor receptor and platelet‐derived growth factor receptor tyrosine kinase inhibitor, shows potent a...

Por Awazu, Yoshiko, Mizutani, Akio, Nagase, Yoshinori, Iwata, Hidehisa, Oguro, Yuya, Miki, Hiroshi, Imamura, Shinichi, Hori, Akira
Publicado no Cancer Sci (2012)

Feedback activation of AMPK-mediated autophagy acceleration is a key resistance mechanism against SCD1 inhibitor-induced cell growth inhibition

Por Ono, Akito, Sano, Osamu, Kazetani, Ken-ichi, Muraki, Takamichi, Imamura, Keisuke, Sumi, Hiroyuki, Matsui, Junji, Iwata, Hidehisa
Publicado no PLoS One (2017)

A Cell-Based High-Throughput Screening Identified Two Compounds that Enhance PINK1-Parkin Signaling

Por Shiba-Fukushima, Kahori, Inoshita, Tsuyoshi, Sano, Osamu, Iwata, Hidehisa, Ishikawa, Kei-ichi, Okano, Hideyuki, Akamatsu, Wado, Imai, Yuzuru, Hattori, Nobutaka
Publicado no iScience (2020)

Structure-Based Approach for the Discovery of Pyrrolo[3,2-d]pyrimidine-Based EGFR T790M/L858R Mutant Inhibitors

Por Sogabe, Satoshi, Kawakita, Youichi, Igaki, Shigeru, Iwata, Hidehisa, Miki, Hiroshi, Cary, Douglas R., Takagi, Terufumi, Takagi, Shinji, Ohta, Yoshikazu, Ishikawa, Tomoyasu
Publicado em 2012

A Back-to-Front Fragment-Based Drug Design Search Strategy Targeting the DFG-Out Pocket of Protein Tyrosine Kinases

Por Iwata, Hidehisa, Oki, Hideyuki, Okada, Kengo, Takagi, Terufumi, Tawada, Michiko, Miyazaki, Yasushi, Imamura, Shinichi, Hori, Akira, Lawson, J. David, Hixon, Mark S., Kimura, Hiroyuki, Miki, Hiroshi
Publicado em 2012

A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells

Por Wakita, Masahiro, Takahashi, Akiko, Sano, Osamu, Loo, Tze Mun, Imai, Yoshinori, Narukawa, Megumi, Iwata, Hidehisa, Matsudaira, Tatsuyuki, Kawamoto, Shimpei, Ohtani, Naoko, Yoshimori, Tamotsu, Hara, Eiji
Publicado no Nat Commun (2020)

Anti‐angiogenic and anti‐tumor effects of TAK‐593, a potent and selective inhibitor of vascular endothelial growth factor and platelet‐derived growth factor receptor tyrosine kinas...

Por Awazu, Yoshiko, Mizutani, Akio, Nagase, Yoshinori, Tsuchiya, Shuntarou, Nakamura, Kazuhide, Kakoi, Yuichi, Kitahara, Osamu, Takeuchi, Toshiyuki, Yamasaki, Seiji, Miyamoto, Naoki, Iwata, Hidehisa, Miki, Hiroshi, Imamura, Shinichi, Hori, Akira
Publicado no Cancer Sci (2013)