A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells

Although cellular senescence acts primarily as a tumour suppression mechanism, the accumulation of senescent cells in vivo eventually exerts deleterious side effects through inflammatory/tumour-promoting factor secretion. Thus, the development of new drugs that cause the specific elimination of sene...

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Udgivet i:Nat Commun
Main Authors: Wakita, Masahiro, Takahashi, Akiko, Sano, Osamu, Loo, Tze Mun, Imai, Yoshinori, Narukawa, Megumi, Iwata, Hidehisa, Matsudaira, Tatsuyuki, Kawamoto, Shimpei, Ohtani, Naoko, Yoshimori, Tamotsu, Hara, Eiji
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7176673/
https://ncbi.nlm.nih.gov/pubmed/32321921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15719-6
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