Organocatalytic Enantioselective Conjugate Addition of Nitromethane to Benzylidene-2-Benzoyl Acetate: Asymmetric Synthesis of ABT – 627, an Endothelin Receptor Antagonist

First catalytic and enantioselective conjugate addition of nitromethane to benzylidene-2-benzoyl acetate has been developed using dihydroquinine derived squaramide catalyst with moderate to high selectivities. Asymmetric total synthesis of ABT-627, a potent ETA receptor antagonist is accomplished ut...

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Vydáno v:Front Chem
Hlavní autoři: Hajra, Saumen, Aziz, Sk Mohammad, Jana, Bibekananda, Hazra, Sunit
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7066299/
https://ncbi.nlm.nih.gov/pubmed/32195223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2020.00135
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