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Organocatalytic Enantioselective Conjugate Addition of Nitromethane to Benzylidene-2-Benzoyl Acetate: Asymmetric Synthesis of ABT – 627, an Endothelin Receptor Antagonist

First catalytic and enantioselective conjugate addition of nitromethane to benzylidene-2-benzoyl acetate has been developed using dihydroquinine derived squaramide catalyst with moderate to high selectivities. Asymmetric total synthesis of ABT-627, a potent ETA receptor antagonist is accomplished ut...

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Detalhes bibliográficos
Publicado no:Front Chem
Main Authors: Hajra, Saumen, Aziz, Sk Mohammad, Jana, Bibekananda, Hazra, Sunit
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7066299/
https://ncbi.nlm.nih.gov/pubmed/32195223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2020.00135
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