Pharmacokinetics and pharmacodynamic effects of ABT-627, an oral ETA selective endothelin antagonist, in humans

AIMS: Endothelins (ETs) may play a role in the pathogenesis of a variety of cardiovascular diseases. The present study was designed to investigate the pharmacokinetic and pharmacodynamic effects of the orally active ETA selective receptor antagonist ABT-627 in healthy humans. METHODS: Healthy volunt...

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Detalhes bibliográficos
Main Authors: Verhaar, Marianne C, Grahn, Amy Y, van Weerdt, Anton W M, Honing, Marina L H, Morrison, Paul J, Yang, Yonghong P, Padley, Robert J, Rabelink, Ton J
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2000
Assuntos:
Pharmacokinetics/Pharmacodynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2015037/
https://ncbi.nlm.nih.gov/pubmed/10848720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2000.00171.x
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