Pharmacokinetics and pharmacodynamics of tezosentan, an intravenous dual endothelin receptor antagonist, following chronic infusion in healthy subjects

AIMS: The purpose of this study was to investigate the tolerability, pharmacokinetics, and pharmacodynamics of tezosentan, an intravenous dual endothelin receptor antagonist, during chronic infusions in healthy male subjects. METHODS: Tezosentan was infused at a rate of 100 mg h(−1) for 6 h (study A...

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Detalhes bibliográficos
Main Authors: Dingemanse, Jasper, Clozel, Martine, van Giersbergen, Paul L M
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2002
Assuntos:
Pharmacokinetics/Pharmacodynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874269/
https://ncbi.nlm.nih.gov/pubmed/11966665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2002.01158.x
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