Single- and multiple-dose tolerability, safety, pharmacokinetics, and pharmacodynamics of the dual endothelin receptor antagonist aprocitentan in healthy adult and elderly subjects

BACKGROUND: Aprocitentan is an orally active, dual endothelin (ET) receptor antagonist developed for the treatment of hypertension in which, despite available treatments, a medical need exists for drugs with a new mechanism of action. SUBJECTS AND METHODS: In this study, the single- and multiple-dos...

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Detalles Bibliográficos
Publicado en:Drug Des Devel Ther
Main Authors: Sidharta, Patricia N, Melchior, Meggane, Kankam, Martin K, Dingemanse, Jasper
Formato: Artigo
Idioma:Inglês
Publicado: Dove Medical Press 2019
Assuntos:
Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6435120/
https://ncbi.nlm.nih.gov/pubmed/30962677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S199051
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