Single- and multiple-dose tolerability, safety, pharmacokinetics, and pharmacodynamics of the dual endothelin receptor antagonist aprocitentan in healthy adult and elderly subjects

BACKGROUND: Aprocitentan is an orally active, dual endothelin (ET) receptor antagonist developed for the treatment of hypertension in which, despite available treatments, a medical need exists for drugs with a new mechanism of action. SUBJECTS AND METHODS: In this study, the single- and multiple-dos...

Full description

Saved in:
Bibliographic Details
Published in:Drug Des Devel Ther
Main Authors: Sidharta, Patricia N, Melchior, Meggane, Kankam, Martin K, Dingemanse, Jasper
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2019
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6435120/
https://ncbi.nlm.nih.gov/pubmed/30962677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S199051
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items