Investigation of mutual pharmacokinetic interactions between macitentan, a novel endothelin receptor antagonist, and sildenafil in healthy subjects

AIM: To study the mutual pharmacokinetic interactions between macitentan, an endothelin receptor antagonist, and sildenafil in healthy male subjects. METHODS: In this open-label, randomized, three way crossover study, 12 healthy male subjects received the following oral treatments: A) a loading dose...

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Bibliographische Detailangaben
Veröffentlicht in:Br J Clin Pharmacol
Hauptverfasser: Sidharta, Patricia N, van Giersbergen, Paul L M, Wolzt, Michael, Dingemanse, Jasper
Format: Artigo
Sprache:Inglês
Veröffentlicht: BlackWell Publishing Ltd 2014
Schlagworte:
Drug Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4243877/
https://ncbi.nlm.nih.gov/pubmed/24962473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12447
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