Effect of Cyclosporine and Rifampin on the Pharmacokinetics of Macitentan, a Tissue-Targeting Dual Endothelin Receptor Antagonist

Macitentan is a dual endothelin receptor antagonist under phase 3 investigation in pulmonary arterial hypertension. We investigated the effect of cyclosporine (Cs) and rifampin on the pharmacokinetics of macitentan and its metabolites ACT-132577 and ACT-373898 in healthy male subjects. In addition,...

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Main Authors: Bruderer, Shirin, Äänismaa, Päivi, Homery, Marie-Claude, Häusler, Stephanie, Landskroner, Kyle, Sidharta, Patricia N., Treiber, Alexander, Dingemanse, Jasper
Formato: Artigo
Idioma:Inglês
Publicado: Springer US 2011
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3282010/
https://ncbi.nlm.nih.gov/pubmed/22189899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-011-9316-3
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