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Macitentan: entry-into-humans study with a new endothelin receptor antagonist
PURPOSE: To study the pharmacokinetics, pharmacodynamics, and tolerability of rising single doses of macitentan, an endothelin receptor antagonist, in healthy male subjects. METHODS: This double-blind, placebo-controlled study was performed in seven groups of eight healthy male subjects. Doses of 0....
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| Glavni autori: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Springer-Verlag
2011
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3169777/ https://ncbi.nlm.nih.gov/pubmed/21541781 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-011-1043-2 |
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