Effect of lopinavir/ritonavir on the pharmacokinetics of selexipag an oral prostacyclin receptor agonist and its active metabolite in healthy subjects

AIMS: This study investigated the effect of a fixed dose combination of lopinavir/ritonavir on the pharmacokinetics (PK) of selexipag and its active metabolite ACT-333679. METHODS: This was an open label, randomized, single centre, two way, crossover study. Twenty healthy male subjects were treated...

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Bibliographic Details
Published in:Br J Clin Pharmacol
Main Authors: Kaufmann, Priska, Niglis, Séverine, Bruderer, Shirin, Segrestaa, Jérôme, Äänismaa, Päivi, Halabi, Atef, Dingemanse, Jasper
Format: Artigo
Language:Inglês
Published: John Wiley & Sons, Ltd 2015
Subjects:
Drug Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4594703/
https://ncbi.nlm.nih.gov/pubmed/25851691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12650
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