Učitavanje...

Effect of gemfibrozil and rifampicin on the pharmacokinetics of selexipag and its active metabolite in healthy subjects

AIMS: Based on in vitro data, there is evidence to suggest that cytochrome P450 (CYP) 2C8 is involved in the metabolism of selexipag and its active metabolite, ACT‐333679. The present study evaluated the possible pharmacokinetic interactions of selexipag with gemfibrozil, a strong CYP2C8 inhibitor,...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:Br J Clin Pharmacol
Glavni autori: Bruderer, Shirin, Petersen‐Sylla, Marc, Boehler, Margaux, Remeňová, Tatiana, Halabi, Atef, Dingemanse, Jasper
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698574/
https://ncbi.nlm.nih.gov/pubmed/28715853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13379
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!